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I think that the first challenge in Pandemic 2 is to figure out, the Madagascar problem, but after that is solved, you have not won anything yet. So, How to destroy human population?

First thing to do is to spread the disease around the world. It is good to start with rodent and keep the disease hidden as long as possible. When the first shipyards are closed, make the disease airborne and
pick up symptoms, which make it spread from human to human, but still try to keep it as hidden as possible. Which one is more important, depends on the the fact, which countries you still need to infect. In other words, do you have to make it move by plane or by humans moving between borders (Peru for example).

Be patient!!! With some luck, you’ll be able to infect the whole World before even any border, shipyard or aeroport is closed.

When the disease has spread, increase the lethal symptom. You could try to build a lethal combination of symptoms, because you do not have evolution points to pick up all. Like fever and sweating do good together. And when everyone is infected, pick up only lethal symptoms.

Some tips

Try to spot big flooding and make the disease waterborne - that will do good.

Vaccine and other counter measures - change the symptoms, make the disease drug resistance to close down more hospitals.

That was only walkthrough, now you go figure out, how to get the top points and let us know.